Projects

The Epilepsy Research Laboratories have a research focus on establishing a better understanding of the basic mechanisms of epilepsy and epileptogenesis. This effort is centered on the overarching idea that only by better understanding the fundamental, underlying determinants driving seizure disorders can we learn to better treat – and someday cure – these devastating neurologic conditions.

Epileptogenesis

In the normal brain, the hippocampus receives input from the neocortex via the entorhinal cortex (EC). In the main canonical trisynaptic excitatory hippocampal network, signals propagate from layer II of the EC to the dentate gyrus (DG) through the perforant pathway....

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Glutamine

GABA

In synaptic vesicles of inhibitory neurons, GABA is locally synthesized mainly by glutamic acid decarboxylase (GAD) and is packaged into vesicles by the vesicular GABA transporter, VGAT. In addition, ...

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Hippocampal Microcircuit Dynamics

Mammalian cortical structures are endowed with the capacity for plasticity, which emerges from a combination of the dynamics of circuit connectivity and function, and the intrinsic function of the neurons within the circuit. ...

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Network Bursts

Computational studies have suggested that stochastic, deterministic, and mixed processes all could be possible determinants of spontaneous, synchronous network bursts. In the present study, using multicellular calcium imaging coupled with fast confocal microscopy......

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Astrocytic Gliosis

Reactive astrocytosis develops in many neurologic diseases including epilepsy. Astrocytotic contributions to pathophysiology are poorly understood. Studies examining this are confounded by comorbidities accompanying reactive astrocytosis.....

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